錢萍

個(gè)人基本簡介

職稱：教授

學(xué)位：理學(xué)博士

畢業(yè)院校：遼寧師范大學(xué)

電子郵件：qianp@sdau.edu.cn，

錢萍，教授，博士生導(dǎo)師。講授本科生的《無機(jī)及分析化學(xué)1》《基礎(chǔ)化學(xué)實(shí)驗(yàn)1&2》《結(jié)構(gòu)化學(xué)》和研究生的《高等物理化學(xué)》等課程。曾獲校第四屆青年教師講課技能比賽一等獎(jiǎng)第一名、山東省首屆微課比賽三等獎(jiǎng)。先后主持國家自然科學(xué)基金和山東省自然科學(xué)基金，以第一作者或通訊作者在《ACS Catalysis》《Journal of Chemical Theory and Computation》《Journal of Chemical Information and Modeling》《Communication Chemistry - Nature》《Protein Science》等國際著名期刊上發(fā)表SCI論文40余篇。

主要經(jīng)歷

學(xué)科方向

蛋白質(zhì)的計(jì)算機(jī)模擬

粘土 - 水分子體系的力場模型建立及分子動(dòng)力學(xué)模擬研究

團(tuán)簇的從頭計(jì)算研究

榮譽(yù)獲獎(jiǎng)

2022/06  山東農(nóng)業(yè)大學(xué)2022屆優(yōu)秀學(xué)士學(xué)位論文指導(dǎo)教師

2021/09  山東農(nóng)業(yè)大學(xué)“教學(xué)質(zhì)量獎(jiǎng)”二等獎(jiǎng)

2018/09  山東農(nóng)業(yè)大學(xué)“我最喜歡的專業(yè)課老師”榮譽(yù)稱號

2018/06  山東農(nóng)業(yè)大學(xué)2018屆優(yōu)秀學(xué)士學(xué)位論文指導(dǎo)教師

2013/09  山東農(nóng)業(yè)大學(xué)第二屆教學(xué)先鋒先進(jìn)個(gè)人

2013/08  山東省高等學(xué)校教師首屆微課教學(xué)比賽三等獎(jiǎng)

2012/09  山東農(nóng)業(yè)大學(xué)第四屆青年教師講課技能比賽一等獎(jiǎng)

2011/03  山東農(nóng)業(yè)大學(xué)“巾幗建功先進(jìn)個(gè)人”榮譽(yù)稱號

2009/12  山東農(nóng)業(yè)大學(xué)第一屆青年教師講課技能比賽二等獎(jiǎng)

科研項(xiàng)目

國家自然科學(xué)基金面上項(xiàng)目：基于極化力場和多尺度模擬研究組蛋白翻譯后修飾crosstalk對 Dot1/Dot1L 酶活性的調(diào)控機(jī)制，2022.01-2025.12，主持

國家自然科學(xué)基金青年項(xiàng)目：粘土-水分子體系力場模型的建立與分子動(dòng)力學(xué)模擬，2010.01-2012.12，主持

山東省自然科學(xué)基金面上項(xiàng)目：基于多尺度模擬和生物學(xué)實(shí)驗(yàn)研究組蛋白泛素化修飾對Dot1L甲基化活性的調(diào)控機(jī)制，2022.01-2024.12，主持

山東省自然科學(xué)基金面上項(xiàng)目：蛋白質(zhì)精氨酸甲基轉(zhuǎn)移酶產(chǎn)物特異性的理論模擬與實(shí)驗(yàn)研究，2017.08-2020.06，主持

代表論著

1.  Deng H, Ma Y, Ren WS, Vuong VQ, Qian P*, Guo H* Structure and Dynamics of the Reactive State for the Histidine Methylation Process and Catalytic Mechanism of SETD3: Insights from Quantum Mechanics/Molecular Mechanics Investigation. ACS Catalysis 2020, 10: 13314-13322. (Top 1區(qū)，IF=13.70)

2.  Zhao YY, Xu XL, Deng H, Wang KN, Rahman A, Ma Y, Shaik F, Wang CM, Qian P*, Guo H* Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β Actin H73K Peptide: Insights from a QM/MM Study. Journal of Chemical Theory and Computation 2023, 19: 349-362. (Top 1區(qū)，IF=6.578)

3.  Ren WS, Rahman A, Jiang KB, Deng H, Zhao YY, Zhang WJ, Liu K, Qian P*, Guo H*, Unraveling the Origins of Changing Product Specificity Properties of Arginine Methyltransferase PRMT7 by the E181D and E181D/Q329A Mutations through QM/MM MD and Free-Energy Simulations. Journal of Chemical Theory and Computation 2022, 18, 2631-2641. (Top 1區(qū)，IF=6.578)

4.  Ren WS, Jiang KB, Deng H, Lu N, Yu T, Guo H*, Qian P* Catalytic Mechanism and Product Specificity of Protein Arginine Methyltransferase PRMT7: A Study from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Theory and Computation 2020, 16, 5301-5312. (Top 1區(qū)，IF=6.578)

5.  Qian P*, Guo HB, Wang L, Guo H* QM/MM Investigation of Substrate and Product Speci?cities of Suv420h2: How Does This Enzyme Generate Dimethylated H4K20 from Monomethylated Substrate? Journal of Chemical Theory and Computation 2017, 13: 2977-2986. (Top 1區(qū)，IF=6.578)

6.  Hintzen JCJ, Ma H, Deng H, Witecha A, Andersen SB, Drozak J, Guo H, Qian P*, Li H*, Mecinovi? J* Histidine Methyltransferase SETD3 Methylates Structurally Diverse Histidine Mimics in Actin. Protein Science 2022, 31: e4305. (2區(qū)，IF=6.993)

7.  Al Temimi AHK, Amatdjais-Groenen HIV, Vijayendar Reddy Y, Blaauw RH, Guo H, Qian P*, Mecinovi? J* The Nucleophilic Amino Group of Lysine is Central for Histone Lysine Methyltransferase Catalysis. Communications Chemistry – Nature 2019, 2: 112. (2區(qū)，IF=7.211)

8.  Al Temimi AHK, van der Wekken-de Bruijne R, Proietti G, Guo H, Qian P*, Mecinovic? J* γ Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones. Bioconjugate Chemistry 2019, 30, 1798-1804. (2區(qū)，IF=6.069)

9.  Yue YF, Ma Y, Qian P*, Guo H* Catalytic Mechanism of the Ubiquitin-Like NEDD8 Transfer in RING E3-E2～NEDD8-Target Complex from QM/MM Free Energy Simulations. Journal of Chemical Information and Modeling, 2018, 58: 422-429. (2區(qū)，IF=6.162)

10.  Qian P*, Guo HB, Yue YF, Wang L, Yang XH, Guo H* Understanding the Catalytic Mechanism of Xanthosine Methyltransferase in Ca?eine Biosynthesis from QM/MM Molecular Dynamics and Free Energy Simulations. Journal of Chemical Information and Modeling 2016, 56: 1755-1761. (2區(qū)，IF=6.162)